Early Scar Treatment using CO2 Fractional Laser Intervention comparing to Hyaluronidase Injection (SYSTEMATIC REVIEW)

Document Type : Review Article

Authors

1 MOH

2 National Institute of Laser Enhanced Sciences, Cairo University

3 Surgery, Faculty of Medicine, Menoufia University

Abstract

Early scar management has evolved significantly during 2020-2025, with CO2 fractional laser therapy and hyaluronidase injection emerging as leading treatments. CO2 laser promotes collagen remodeling, improving scar texture especially for atrophic scars, but risks include erythema and hyperpigmentation in darker skin. Hyaluronidase breaks down hyaluronic acid, reducing scar volume with minimal side effects, proving effective for hypertrophic scars and filler complications.
CO2 laser provides comprehensive results but requires 3-5 sessions ($400-$1,500 each) with longer recovery. Hyaluronidase offers faster results in 1-3 sessions ($200-$600 each), often showing improvement after one application. Treatment selection depends on scar type, location, recovery tolerance, and cost considerations.
Combination therapy shows promise for complex scars despite higher costs. This review emphasizes individualizing treatment plans based on patient needs and scar characteristics. Future research should address long-term outcomes, combination approaches, and standardized protocols as both treatments continue to play crucial roles in achieving optimal aesthetic and functional outcomes.

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Journal of Laser Science and Applications
Volume 2, Issue 1
June 2025
Pages 107-110

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